Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 7/20 | 0.58 |
| ▸ | INSR | P06213 | 5/20 | 0.58 |
| ▸ | JAK2 | O60674 | 16/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2502412 | 0.91 | ALK (0.55) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL2529123 | 0.86 | ALK (0.53) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL16531842 | 0.84 | ALK (0.84) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL2524303 | 0.82 | ALK (0.54) | ALKINSRJAK2CYP3A4 | |
| SCHEMBL2550810 | 0.81 | ALK (0.58) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL2528848 | 0.80 | ALK (0.46) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL2524256 | 0.80 | ALK (0.64) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL2524799 | 0.78 | ALK (0.63) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL2509642 | 0.78 | ALK (0.44) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL521162 | 0.78 | ALK (0.71) | ALKINSRJAK2CYP3A4PTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |