Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 6/20 | 0.46 |
| ▸ | INSR | P06213 | 4/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.39 |
| ▸ | FEN1 | P39748 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 8/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPM1 | P06748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2521922 | 0.85 | BRPF1 (0.36) | ALKINSRSLC22A12ALOX5APFEN1 | |
| SCHEMBL2523523 | 0.84 | ALK (0.36) | ALKINSRSLC22A12JAK2CYP3A4 | |
| SCHEMBL2509642 | 0.84 | ALK (0.44) | ALKINSRPARP14SLC22A12PSIP1 | |
| SCHEMBL2498821 | 0.82 | ALK (0.43) | ALKINSRPARP14SLC22A12PSIP1 | |
| SCHEMBL2509793 | 0.81 | ALOX5AP (0.39) | PARP14SLC22A12PSIP1ALOX5APFEN1 | |
| SCHEMBL2526580 | 0.80 | ALK (0.58) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL2507426 | 0.79 | ALK (0.43) | ALKINSRPARP14SLC22A12PSIP1 | |
| SCHEMBL2502412 | 0.79 | ALK (0.55) | ALKINSRJAK2CYP3A4PTK2 | |
| SCHEMBL16531842 | 0.74 | ALK (0.84) | ALKINSRJAK2CYP3A4NPM1 | |
| SCHEMBL2524303 | 0.74 | ALK (0.54) | ALKINSRJAK2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |