Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.74 |
| ▸ | IKZF3 | Q9UKT9 | 17/20 | 0.74 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.74 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.74 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.74 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.74 |
| ▸ | DRD2 | P14416 | 1/20 | 0.61 |
| ▸ | TNF | P01375 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25209599 | 1.00 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL30447297 | 1.00 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25201841 | 1.00 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25227292 | 0.92 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL31308183 | 0.92 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25227289 | 0.92 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25208232 | 0.92 | CRBN (0.74) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25209797 | 0.92 | CRBN (0.81) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25225391 | 0.92 | CRBN (0.81) | CRBNIKZF3DDB1ADRA1DADRA1A | |
| SCHEMBL25223071 | 0.92 | CRBN (0.81) | CRBNIKZF3DDB1ADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230257366-A1 | SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2023-08-17 | — | — | US | disclosed |
| US-20230257366-A1 | SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2023-08-17 | — | — | US | disclosed |
| US-20230257366-A1 | SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2023-08-17 | — | — | US | disclosed |
| EP-4183781-A1 | SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-05-24 | — | — | EP | disclosed |
| EP-4183781-A1 | SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Jiangsu Hengrui Pharmaceuticals Co., Ltd. (CN) | 2023-05-24 | — | — | EP | disclosed |
| CN-115916768-A | Sulfur-containing isoindoline derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2023-04-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230257366-A1 | SULFUR-CONTAINING ISOINDOLINE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | CRBN, CBS, MGMT | CRBN 1/4885IKZF3 1207/4885DDB1 4140/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.