Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.36 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.36 |
| ▸ | IL1B | P01584 | 4/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | CCNH | P51946 | 1/20 | 0.34 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30533952 | 1.00 | KMT2A (0.36) | KMT2ACCNKCDK12IL1BNLRP3 | |
| SCHEMBL25217556 | 1.00 | KMT2A (0.36) | KMT2ACCNKCDK12IL1BNLRP3 | |
| SCHEMBL25263288 | 0.89 | CCNK (0.38) | KMT2ACCNKCDK12IL1BNLRP3 | |
| SCHEMBL30533989 | 0.89 | CCNK (0.38) | KMT2ACCNKCDK12IL1BNLRP3 | |
| SCHEMBL25216715 | 0.89 | CCNK (0.38) | KMT2ACCNKCDK12IL1BNLRP3 | |
| SCHEMBL30533949 | 0.85 | ALDH1A1 (0.41) | KMT2ACCNKCDK12MEN1LMNA | |
| SCHEMBL25260927 | 0.85 | ALDH1A1 (0.41) | KMT2ACCNKCDK12MEN1LMNA | |
| SCHEMBL25219563 | 0.85 | ALDH1A1 (0.41) | KMT2ACCNKCDK12MEN1LMNA | |
| SCHEMBL25219479 | 0.84 | HCRTR1 (0.37) | KMT2AIL1BNLRP3MCHR1HCRTR1 | |
| SCHEMBL25261654 | 0.84 | HCRTR1 (0.37) | KMT2AIL1BNLRP3MCHR1HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | INCYTE CORPORATION | 2023-06-29 | — | — | US | disclosed |
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203010-A1 | BICYCLIC AMINE CDK12 INHIBITORS | CDK12, CDK1, CDK2 | KMT2A 289/4885CCNK 17/4885CDK12 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.