Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 9/20 | 0.43 |
| ▸ | CCNH | P51946 | 9/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 9/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 7/20 | 0.43 |
| ▸ | CDK9 | P50750 | 7/20 | 0.43 |
| ▸ | CCNK | O75909 | 16/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 15/20 | 0.42 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 8/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30439347 | 1.00 | CDK7 (0.43) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL29509244 | 0.92 | CDK7 (0.40) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL24087391 | 0.92 | CDK7 (0.40) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL30203949 | 0.91 | CDK7 (0.42) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL30204452 | 0.90 | CDK7 (0.42) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL24087388 | 0.90 | CCNK (0.49) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL29509168 | 0.90 | CCNK (0.49) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL24087348 | 0.89 | HDAC4 (0.46) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL29509197 | 0.89 | HDAC4 (0.46) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL30204122 | 0.89 | CCNK (0.46) | CDK7CCNHMNAT1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4295852-A2 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | Syros Pharmaceuticals, Inc. (US) | 2023-12-27 | — | — | EP | disclosed |
| EP-3484871-B1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF CYCLIN DEPENDENT KINASE 7 (CDK7) | SYROS PHARMACEUTICALS INC (US) | 2023-06-07 | — | — | EP | disclosed |