SCHEMBL25269700

SCHEMBL25269700

Cc1cc(-c2ccncc2C2CCN(C(=O)OC(C)(C)C)CC2)ccc1CNC(=O)c1noc(C(C)(C)C)n1

nearest known ligand 0.48

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ BTK Q06187 9/20 0.48
▸ LCK P06239 1/20 0.45
▸ GPR119 Q8TDV5 5/20 0.42
▸ HDAC4 P56524 1/20 0.41
▸ NAMPT P43490 2/20 0.40
▸ POLB P06746 1/20 0.39
▸ TP53 P04637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29418394 1.00 BTK (0.48) BTKLCKGPR119HDAC4NAMPT
SCHEMBL25267864 0.89 BTK (0.49) BTKLCK
SCHEMBL29418369 0.89 BTK (0.49) BTKLCK
SCHEMBL29418480 0.88 BTK (0.48) BTKLCKGPR119HDAC4NAMPT
SCHEMBL25214221 0.88 BTK (0.48) BTKLCKGPR119HDAC4NAMPT
SCHEMBL30599726 0.86 BTK (0.48) BTKLCK
SCHEMBL29124651 0.86 BTK (0.48) BTKLCK
Hydrochloric Acid SCHEMBL25246453 0.85 BTK (0.53) BTKLCK
Hydrochloric Acid SCHEMBL29418446 0.85 BTK (0.53) BTKLCK
SCHEMBL29124828 0.83 BTK (0.47) BTKLCK

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240327380-A1 BTK INHIBITORS BIOGEN MA INC. (US) 2024-10-03 — — US disclosed
CN-116917279-A BTK inhibitors 渤健马萨诸塞州股份有限公司 2023-10-20 — — CN disclosed
EP-4192587-A1 BTK INHIBITORS Biogen MA Inc. (US) 2023-06-14 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240327380-A1 BTK INHIBITORS BTK, SYK, LYN BTK 1/4885LCK 7/4885GPR119 1014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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