Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 12/20 | 0.67 |
| ▸ | INSR | P06213 | 10/20 | 0.67 |
| ▸ | NPM1 | P06748 | 9/20 | 0.67 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 4/20 | 0.49 |
| ▸ | TTK | P33981 | 1/20 | 0.48 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520392 | 0.93 | ALK (0.71) | ALKINSRNPM1JAK2EGFR | |
| SCHEMBL2512614 | 0.88 | ALK (0.75) | ALKINSRNPM1JAK2TTK | |
| SCHEMBL521711 | 0.85 | ALK (0.77) | ALKINSRNPM1JAK2EGFR | |
| SCHEMBL16530397 | 0.84 | ALK (0.62) | ALKINSRNPM1JAK2EGFR | |
| SCHEMBL521467 | 0.84 | ALK (0.67) | ALKINSRNPM1JAK2EGFR | |
| SCHEMBL16531165 | 0.84 | ALK (0.70) | ALKINSRNPM1JAK2EGFR | |
| SCHEMBL2523374 | 0.83 | ALK (0.72) | ALKINSRNPM1JAK2TTK | |
| SCHEMBL520257 | 0.83 | INSR (0.59) | ALKINSRNPM1JAK2 | |
| SCHEMBL16530449 | 0.83 | INSR (0.68) | ALKINSRJAK2 | |
| SCHEMBL521279 | 0.83 | ALK (0.60) | ALKINSRNPM1JAK2EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |