⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25272296 | 0.80 | — | — | |
| SCHEMBL3989665 | 0.70 | KDM4E (0.41) | — | |
| SCHEMBL21404989 | 0.68 | — | — | |
| SCHEMBL9364886 | 0.68 | NPSR1 (0.39) | — | |
| SCHEMBL16502353 | 0.67 | KDM4E (0.33) | — | |
| SCHEMBL9644936 | 0.67 | KDM4E (0.52) | — | |
| SCHEMBL25277108 | 0.66 | — | — | |
| SCHEMBL22019930 | 0.64 | NLRP3 (0.31) | — | |
| SCHEMBL12866968 | 0.63 | KDM4E (0.31) | — | |
| SCHEMBL27247680 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250101003-A1 | SPIROCYCLIC CAV2.3 ANTAGONISTS | LARIO THERAPEUTICS LIMITED (GB) | 2025-03-27 | — | — | US | disclosed |
| EP-4436661-A1 | SPIROCYCLIC CAV2.3 ANTAGONISTS | Lario Therapeutics Limited (GB) | 2024-10-02 | — | — | EP | disclosed |
| WO-2023094827-A1 | SPIROCYCLIC CAV2.3 ANTAGONISTS | LARIO THERAPEUTICS LIMITED (GB) | 2023-06-01 | — | — | WO | disclosed |