Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPM1B | O75688 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31010895 | 1.00 | PPM1B (0.53) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL31010896 | 1.00 | PPM1B (0.53) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL14357831 | 0.90 | PPM1B (0.49) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL15646197 | 0.87 | PPM1B (0.57) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL15645793 | 0.87 | PPM1B (0.57) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL15645791 | 0.87 | PPM1B (0.57) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL15647516 | 0.87 | PPM1B (0.57) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 | |
| SCHEMBL7354850 | 0.87 | PPM1B (0.45) | PPM1BPTPN1PPP1CCSMN1; SMN2CHRM2 | |
| SCHEMBL16448666 | 0.87 | PPM1B (0.45) | PPM1BPTPN1PPP1CCSMN1; SMN2CHRM2 | |
| SCHEMBL6551846 | 0.87 | PPM1B (0.45) | PPM1BPTPN1PPP1CCPOLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448483-A1 | BICYCLO [3.2.0] HEPTANE BIS(AMIDE) RXFP1 AGONISTS | Bristol-Myers Squibb Company (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114824-A1 | BICYCLO [3.2.0] HEPTANE BIS(AMIDE) RXFP1 AGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-22 | — | — | WO | disclosed |