Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.72 |
| ▸ | MMP2 | P08253 | 18/20 | 0.72 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.72 |
| ▸ | MMP9 | P14780 | 12/20 | 0.72 |
| ▸ | MMP3 | P08254 | 6/20 | 0.72 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
| ▸ | MMP14 | P50281 | 1/20 | 0.58 |
| ▸ | ADAM8 | P78325 | 1/20 | 0.58 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.58 |
| ▸ | ADAM33 | Q9BZ11 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2530093 | 1.00 | ADAM10 (0.72) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL2526870 | 0.94 | ADAM10 (0.69) | ADAM10MMP2ERBB2MMP9MMP3 | |
| Aderbasib SCHEMBL206421 | 0.92 | ADAM10 (0.76) | ADAM10MMP2ERBB2MMP9MMP3 | |
| Aderbasib SCHEMBL1366560 | 0.92 | ADAM10 (0.76) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1364313 | 0.91 | ADAM10 (0.70) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1366083 | 0.88 | ADAM10 (0.71) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1366801 | 0.88 | ADAM10 (0.71) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL4638822 | 0.87 | ADAM10 (0.79) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3648643 | 0.87 | ADAM10 (0.79) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1366079 | 0.84 | ADAM10 (1.00) | ADAM10MMP2ERBB2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039471-B2 | Aza spiro alkane derivatives as inhibitors of metalloproteases | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | claimed |
| US-8039471-B2 | Aza spiro alkane derivatives as inhibitors of metalloproteases | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |