SCHEMBL25280331

SCHEMBL25280331

COc1ccc(C(=O)C=Cc2cccc(O)c2)c(OC)c1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.78
NPC1 O15118 2/20 0.78
RAB9A P51151 2/20 0.78
MEN1 O00255 2/20 0.78
KMT2A Q03164 2/20 0.78
XDH P47989 1/20 0.76
ABCG2 Q9UNQ0 9/20 0.75
TNFRSF1A P19438 1/20 0.73
NR1H4 Q96RI1 2/20 0.69
CYP1A2 P05177 2/20 0.68
CYP3A4 P08684 2/20 0.68
CYP2D6 P10635 2/20 0.68
CYP1A1 P04798 1/20 0.68
CYP1B1 Q16678 1/20 0.68
L3MBTL1 Q9Y468 2/20 0.66
LMNA P02545 1/20 0.66
RECQL P46063 1/20 0.66
ATM Q13315 1/20 0.66
ABCB1 P08183 1/20 0.65
CYP2C9 P11712 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25198778 1.00 MAPT (0.78) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL29443563 0.92 MAPT (0.82) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL21527675 0.89 ABCG2 (0.90) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL21527674 0.89 ABCG2 (0.90) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL25185009 0.89 ABCG2 (0.90) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL30138915 0.88 MAPT (0.76) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL4030789 0.88 MAPT (1.00) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL4030793 0.88 MAPT (1.00) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL10614312 0.87 MAPT (0.74) MAPTNPC1RAB9AMEN1KMT2A
SCHEMBL10614308 0.87 MAPT (0.74) MAPTNPC1RAB9AMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders YEWSAVIN INC (US) 2026-01-15 US disclosed
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders YewSavin, Inc. (US) 2025-07-01 US disclosed
WO-2024233598-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2024-11-14 WO disclosed
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS YewSavin, Inc. (US) 2023-06-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260014100-A1 Compositions and Methods for Treating Bleeding and Bleeding Disorders SERPINC1, F2, F13B MAPT 3297/4885NPC1 1378/4885RAB9A 480/4885
US-20230190679-A1 COMPOSITIONS AND METHODS FOR TREATING BLEEDING AND BLEEDING DISORDERS SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885NPC1 1908/4885RAB9A 1327/4885
US-12343317-B2 Compositions and methods for treating bleeding and bleeding disorders SERPINC1, SERPINE1, SERPINH1 MAPT 3512/4885NPC1 1908/4885RAB9A 1327/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.