Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM10 | O14672 | 20/20 | 0.60 |
| ▸ | MMP2 | P08253 | 19/20 | 0.60 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.60 |
| ▸ | MMP9 | P14780 | 12/20 | 0.55 |
| ▸ | MMP3 | P08254 | 7/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1367687 | 0.88 | ADAM10 (0.58) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL209094 | 0.88 | ADAM10 (0.64) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1366806 | 0.85 | ADAM10 (0.60) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1364457 | 0.83 | ADAM10 (0.61) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1364256 | 0.83 | ADAM10 (0.61) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL4638822 | 0.82 | ADAM10 (0.79) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL3648643 | 0.82 | ADAM10 (0.79) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1366014 | 0.82 | ADAM10 (0.62) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1364063 | 0.81 | ADAM10 (0.59) | ADAM10MMP2ERBB2MMP9MMP3 | |
| SCHEMBL1365531 | 0.81 | ADAM10 (0.59) | ADAM10MMP2ERBB2MMP9MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8039471-B2 | Aza spiro alkane derivatives as inhibitors of metalloproteases | INCYTE CORPORATION (US) | 2011-10-18 | — | — | US | disclosed |