Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 4/20 | 0.42 |
| ▸ | MAOA | P21397 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12035589 | 1.00 | MAPT (0.52) | MAPTMAPK1CYP2C19POLBKDM1A | |
| SCHEMBL9989762 | 0.93 | MAPT (0.55) | MAPTMAPK1CYP2C19POLBKDM1A | |
| SCHEMBL5961926 | 0.93 | MAPT (0.55) | MAPTMAPK1CYP2C19POLBKDM1A | |
| SCHEMBL28279218 | 0.86 | OPRK1 (0.44) | MAPTKDM1AKMT2AHTTSLC6A3 | |
| SCHEMBL2074640 | 0.86 | MAPT (0.40) | MAPTKDM1AMEN1KMT2ASLC6A3 | |
| SCHEMBL5435422 | 0.84 | MAPK1 (0.50) | MAPK1CYP2C19KDM1AMAOAMAOB | |
| SCHEMBL7394507 | 0.83 | SMN1; SMN2 (0.56) | CYP2C19GAASMN1; SMN2HTT | |
| SCHEMBL7394511 | 0.83 | SMN1; SMN2 (0.56) | CYP2C19GAASMN1; SMN2HTT | |
| SCHEMBL7394508 | 0.83 | SMN1; SMN2 (0.56) | CYP2C19GAASMN1; SMN2HTT | |
| SCHEMBL19612364 | 0.80 | MAPT (0.49) | MAPTMAPK1CYP2C19POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376408-A2 | FLUORINATION OF ORGANIC COMPOUNDS | President and Fellows of Harvard College (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010059943-A2 | FLUORINATION OF ORGANIC COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-05-27 | — | — | WO | disclosed |