Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.56 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.56 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.56 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.56 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | F7 | P08709 | 3/20 | 0.50 |
| ▸ | F3 | P13726 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 2/20 | 0.50 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | FABP3 | P05413 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28593996 | 0.93 | ESR1 (0.49) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL28572328 | 0.93 | ESR1 (0.49) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL22289842 | 0.89 | ESR1 (0.69) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL29263833 | 0.89 | ESR1 (0.69) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL22503890 | 0.87 | ESR1 (0.53) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL16013155 | 0.87 | ESR1 (0.53) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL16013154 | 0.87 | ESR1 (0.53) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL17685778 | 0.87 | ESR1 (0.53) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL16154819 | 0.87 | ESR1 (0.53) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 | |
| SCHEMBL25285062 | 0.86 | ESR1 (0.52) | ESR1AKR1C3AKR1C4AKR1C2AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4452930-A1 | IONIZABLE AMINE AND ESTER LIPIDS AND LIPID NANOPARTICLES | Beam Therapeutics Inc. (US) | 2024-10-30 | — | — | EP | disclosed |
| US-20240335543-A1 | IONIZABLE AMINE AND ESTER LIPIDS AND LIPID NANOPARTICLES | BEAM THERAPEUTICS INC. | 2024-10-10 | — | — | US | disclosed |
| WO-2023121970-A1 | IONIZABLE AMINE AND ESTER LIPIDS AND LIPID NANOPARTICLES | BEAM THERAPEUTICS INC. (US) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023121970-A1 | IONIZABLE AMINE AND ESTER LIPIDS AND LIPID NANOPARTICLES | BEAM THERAPEUTICS INC. (US) | 2023-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240335543-A1 | IONIZABLE AMINE AND ESTER LIPIDS AND LIPID NANOPARTICLES | PHOSPHO1, SGMS1, SGMS2 | ESR1 1091/4885AKR1C3 3429/4885AKR1C4 3704/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.