⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL645101 | 0.71 | — | — | |
| SCHEMBL10802510 | 0.71 | — | — | |
| SCHEMBL1028042 | 0.67 | — | — | |
| SCHEMBL1800566 | 0.67 | — | — | |
| SCHEMBL5629839 | 0.67 | — | — | |
| SCHEMBL20885 | 0.67 | — | — | |
| SCHEMBL20722189 | 0.67 | — | — | |
| SCHEMBL4426803 | 0.63 | CYP3A4 (0.48) | — | |
| SCHEMBL5846326 | 0.62 | — | — | |
| SCHEMBL14829594 | 0.62 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190070305-A1 | BENZODIAZEPINES AND CONJUGATES THEREOF | IMMUNOGEN, INC. | 2019-03-07 | — | — | US | disclosed |
| US-20180134717-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2018-05-17 | — | — | US | disclosed |
| US-20170274091-A1 | BENZODIAZEPINES AND CONJUGATES THEREOF | IMMUNOGEN, INC. | 2017-09-28 | — | — | US | disclosed |
| US-9555125-B2 | Benzodiazepines and conjugates thereof | IMMUNOGEN, INC. (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160106861-A1 | AXL ANTIBODY-DRUG CONJUGATE AND ITS USE FOR THE TREATMENT OF CANCER | SPIROGEN SARL (CH) | 2016-04-21 | — | — | US | disclosed |
| US-20150209444-A1 | BENZODIAZEPINES AND CONJUGATES THEREOF | IMMUNOGEN, INC. (US) | 2015-07-30 | — | — | US | disclosed |
| CN-102933236-B | Pyrrolobenzodiazepines and conjugates thereof | SPIROGEN LTD. (CH) | 2014-10-08 | — | — | CN | disclosed |
| WO-2013177481-A1 | BENZODIAZEPINES AND CONJUGATES THEREOF | IMMUNOGEN, INC. (US) | 2013-11-28 | — | — | WO | disclosed |
| EP-2662095-A1 | Pyrrolobenzodiazepines and conjugates thereof | Spirogen Sàrl (CH) | 2013-11-13 | — | — | EP | disclosed |
| EP-2528625-B1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN SARL (CH) | 2013-07-10 | — | — | EP | disclosed |
| CN-102933236-A | Pyrrolobenzodiazepines and conjugates thereof | SPIROGEN LTD | 2013-02-13 | — | — | CN | disclosed |
| US-20130028917-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN DEVELOPMENTS SÀRL (CH) | 2013-01-31 | — | — | US | disclosed |
| EP-2528625-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | Spirogen Developments SARL (CH) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011130598-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2011-10-20 | — | — | WO | disclosed |
| US-20110256157-A1 | PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF | SPIROGEN LIMITED (GB) | 2011-10-20 | — | — | US | disclosed |