Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 10/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25242554 | 0.89 | POLB (0.47) | POLBGAATYK2JAK1EGFR | |
| SCHEMBL25244650 | 0.88 | TYK2 (0.59) | POLBGAATYK2JAK1MAPT | |
| SCHEMBL25288507 | 0.88 | POLB (0.46) | POLBGAATYK2JAK1AKR1C3 | |
| SCHEMBL25288626 | 0.85 | TYK2 (0.45) | POLBGAATYK2JAK1EGFR | |
| SCHEMBL25292550 | 0.85 | TYK2 (0.44) | POLBGAATYK2JAK1EGFR | |
| SCHEMBL25283977 | 0.85 | TYK2 (0.50) | POLBGAATYK2JAK1 | |
| SCHEMBL25239536 | 0.84 | TYK2 (0.47) | POLBGAATYK2JAK1AKR1C3 | |
| SCHEMBL25248111 | 0.83 | TYK2 (0.65) | POLBGAATYK2JAK1 | |
| SCHEMBL25293421 | 0.82 | GAA (0.53) | POLBGAATYK2JAK1EGFR | |
| SCHEMBL25282403 | 0.81 | GRM5 (0.43) | POLBGAATYK2JAK1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | claimed |
| EP-4206196-A1 | PYRIMIDINE SUBSTITUTED DERIVATIVES AS TYK2 INHIBITORS | Almirall S.A. (ES) | 2023-07-05 | — | — | EP | disclosed |