Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 8/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MPI | P34949 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.31 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.31 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25251614 | 0.80 | IRAK4 (0.32) | IRAK4GRM2 | |
| SCHEMBL31489919 | 0.80 | IRAK4 (0.32) | IRAK4GRM2 | |
| SCHEMBL25249176 | 0.76 | POLB (0.44) | IRAK4ALDH1A1 | |
| SCHEMBL25291980 | 0.70 | IRAK4 (0.32) | IRAK4 | |
| SCHEMBL21326683 | 0.67 | LMNA (0.36) | IRAK4ALDH1A1HTTCYP3A4 | |
| SCHEMBL9101781 | 0.66 | KDM4E (0.52) | KDM4EALDH1A1GAACSNK2A2CSNK2B | |
| SCHEMBL9101771 | 0.66 | KDM4E (0.52) | KDM4EALDH1A1GAACSNK2A2CSNK2B | |
| SCHEMBL6677378 | 0.63 | KDM4E (0.51) | KDM4EALDH1A1GAAHTT | |
| SCHEMBL6677372 | 0.63 | KDM4E (0.51) | KDM4EALDH1A1GAAHTT | |
| SCHEMBL19834782 | 0.62 | MIF (0.50) | MIFKDM4EALDH1A1GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130054-A2 | HETEROARYL COMPOUNDS AS INHIBITORS OF IRAK4, COMPOSITIONS AND APPLICATIONS THEREOF | ACCRO BIOSCIENCE (HK) LIMITED (CN) | 2023-07-06 | — | — | WO | disclosed |