Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 5/20 | 0.35 |
| ▸ | RET | P07949 | 5/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.35 |
| ▸ | CDK7 | P50613 | 4/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 4/20 | 0.34 |
| ▸ | JAK2 | O60674 | 3/20 | 0.34 |
| ▸ | GSK3B | P49841 | 3/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25781990 | 0.77 | COMT (0.39) | COMTBRD4SMN1; SMN2ROCK1PIK3CD | |
| SCHEMBL25403950 | 0.76 | CCNE1 (0.41) | COMTABL1BRD4AURKALATS1 | |
| SCHEMBL12521256 | 0.75 | PTGES (0.35) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL4840365 | 0.71 | SMN1; SMN2 (0.41) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL4843914 | 0.71 | KDR (0.57) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL2984405 | 0.71 | ABL1 (0.41) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL25781891 | 0.71 | COMT (0.43) | COMTABL1RETKDRCDK7 | |
| SCHEMBL31588150 | 0.71 | SMN1; SMN2 (0.53) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL1192302 | 0.71 | SMN1; SMN2 (0.53) | ABL1RETKDRCDK7CDK5 | |
| SCHEMBL13607760 | 0.71 | PTGES (0.51) | KDRCDK5AURKBCLK4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023168686-A1 | SUBSTITUTED CYCLOPENTANES AS CDK2 INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2023-09-14 | — | — | WO | disclosed |
| WO-2023168686-A1 | SUBSTITUTED CYCLOPENTANES AS CDK2 INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2023-09-14 | — | — | WO | disclosed |
| WO-2023116884-A1 | CDK2 INHIBITORS AND USE THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2023-06-29 | — | — | WO | disclosed |
| WO-2023116884-A1 | CDK2 INHIBITORS AND USE THEREOF | QILU REGOR THERAPEUTICS INC. (CN) | 2023-06-29 | — | — | WO | disclosed |