Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 13/20 | 0.70 |
| ▸ | HTR2C | P28335 | 5/20 | 0.63 |
| ▸ | HTR2B | P41595 | 5/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25243946 | 0.83 | HTR2A (0.66) | HTR2AHTR2CHTR2BMAPK1MAPK8 | |
| SCHEMBL25244796 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR2B | |
| SCHEMBL25243167 | 0.80 | HTR2A (0.63) | HTR2AHTR2CHTR2B | |
| SCHEMBL25246383 | 0.80 | HTR2A (0.62) | HTR2AHTR2CHTR2BMAPK8MAPK9 | |
| SCHEMBL25244788 | 0.78 | HTR2A (1.00) | HTR2AHTR2CHTR2BMAP2K4MAPK10 | |
| SCHEMBL25252404 | 0.77 | HTR2A (0.54) | HTR2AMAPK1MAP2K4MAPKAPK2MAPK6 | |
| SCHEMBL25293913 | 0.74 | HTR2A (1.00) | HTR2AHTR2CHTR2BADRA2A | |
| SCHEMBL25245918 | 0.73 | HTR2A (0.71) | HTR2AHTR2CHTR2B | |
| SCHEMBL29968044 | 0.69 | KDR (0.60) | HTR2AHTR2CHTR2BMAPK8MAPK9 | |
| SCHEMBL31287956 | 0.69 | HTR2A (0.50) | HTR2AHTR2CHTR2BADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4447954-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | Icahn School of Medicine at Mount Sinai (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114472-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-06-22 | — | — | WO | disclosed |
| WO-2023114472-A1 | HETEROCYCLIC COMPOUNDS AS 5HT2A BIASED AGONISTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-06-22 | — | — | WO | disclosed |