Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 3/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | QPCT | Q16769 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30245164 | 1.00 | NPC1 (0.38) | NPC1MAPTAGXTKITFLT3 | |
| SCHEMBL29194746 | 0.94 | KIT (0.39) | KITFLT3QPCTDRD2JAK2 | |
| SCHEMBL30245083 | 0.94 | KIT (0.39) | KITFLT3QPCTDRD2JAK2 | |
| SCHEMBL30245826 | 0.94 | QPCT (0.37) | NPC1MAPTAGXTKDM4EGFER | |
| SCHEMBL25260059 | 0.94 | QPCT (0.37) | NPC1MAPTAGXTKDM4EGFER | |
| SCHEMBL30245502 | 0.92 | FGFR1 (0.42) | NPC1MAPTAGXTKDM4EGFER | |
| SCHEMBL29194662 | 0.92 | FGFR1 (0.42) | NPC1MAPTAGXTKDM4EGFER | |
| SCHEMBL30245577 | 0.91 | AGXT (0.44) | NPC1MAPTAGXTKITFLT3 | |
| SCHEMBL25296186 | 0.90 | AGXT (0.43) | NPC1MAPTAGXTKITFLT3 | |
| SCHEMBL30245435 | 0.90 | AGXT (0.43) | NPC1MAPTAGXTKITFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117916237-A | Amino aryl integrin agonist compounds | 德克萨斯心脏研究所 | 2024-04-19 | — | — | CN | claimed |
| CN-117916237-A | Amino aryl integrin agonist compounds | 德克萨斯心脏研究所 | 2024-04-19 | — | — | CN | disclosed |
| WO-2023018472-A9 | AMINOARYL-INTEGRIN AGONISTS COMPOUNDS | TEXAS HEART INSTITUTE (US) | 2023-07-13 | — | — | WO | disclosed |