SCHEMBL25296709

SCHEMBL25296709

C[SiH](C)OC(CCNc1ccc(Br)nc1)C(C)(C)C

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FDFT1 P37268 1/20 0.33
CYP26A1 O43174 2/20 0.31
SLC6A2 P23975 1/20 0.31
SLC6A4 P31645 1/20 0.31
SLC6A3 Q01959 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25253886 0.71 FDFT1 (0.38) FDFT1CYP26A1SLC6A2SLC6A4SLC6A3
SCHEMBL25298229 0.68 KCNH3 (0.48) FDFT1
SCHEMBL7765123 0.68 KMT2A (0.40)
Hydrochloric Acid SCHEMBL1871520 0.68 FDFT1 (0.44) FDFT1SLC6A2SLC6A4SLC6A3
SCHEMBL3298698 0.68 FDFT1 (0.33) FDFT1CYP26A1SLC6A2SLC6A4SLC6A3
SCHEMBL4773585 0.68 GBA1 (0.34)
SCHEMBL16943126 0.67 MAPT (0.43) FDFT1SLC6A2SLC6A4SLC6A3
SCHEMBL2171131 0.67 RRM2 (0.47) FDFT1
SCHEMBL508699 0.66 CYP26A1 (0.31) CYP26A1
SCHEMBL23579386 0.66 FDFT1 (0.41) FDFT1SLC6A2SLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4208454-A1 IMIDAZOLE-PYRAZOLE DERIVATIVES WITH ANTI-BACTERIAL PROPERTIES F. Hoffmann-La Roche AG (CH) 2023-07-12 EP disclosed