Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3500649 | 0.81 | FFAR1 (0.56) | GRM5KCNH2FFAR1TRPA1 | |
| SCHEMBL19121162 | 0.78 | GRM5 (0.54) | GRM5KCNH2FFAR1ADRB3TSPO | |
| SCHEMBL4734297 | 0.77 | FFAR1 (0.50) | GRM5KCNH2FFAR1ADRB3TSPO | |
| SCHEMBL19121065 | 0.77 | GRM5 (0.53) | GRM5KCNH2FFAR1ADRB3TSPO | |
| SCHEMBL23481153 | 0.77 | GRM5 (0.53) | GRM5KCNH2FFAR1ADRB3TSPO | |
| SCHEMBL19121124 | 0.75 | GRM5 (0.57) | GRM5KCNH2FFAR1ADRB3TSPO | |
| SCHEMBL9947880 | 0.75 | FFAR1 (0.46) | GRM5KCNH2FFAR1ADRB3TSPO | |
| Basimglurant SCHEMBL560590 | 0.74 | GRM5 (1.00) | GRM5KCNH2FFAR1ADRB3TSPO | |
| SCHEMBL2172336 | 0.74 | GRM5 (0.78) | GRM5KCNH2FFAR1ADRB3TSPO | |
| Basimglurant SCHEMBL29377966 | 0.74 | GRM5 (1.00) | GRM5KCNH2FFAR1ADRB3TSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2556073-B1 | BICYCLIC PYRIDINYL PYRAZOLES | BAYER IP GMBH (DE) | 2014-07-23 | — | — | EP | disclosed |
| US-8507472-B2 | Bicyclic pyridinylpyrazoles | BAYER CROPSCIENCE AG (DE) | 2013-08-13 | — | — | US | disclosed |
| CN-102947303-A | Bicyclic pyrimidinyl pyrazoles | BAYER CROPSCIENCE AG | 2013-02-27 | — | — | CN | disclosed |
| EP-2556073-A1 | BICYCLIC PYRIMIDINYL PYRAZOLES | Bayer Intellectual Property GmbH (DE) | 2013-02-13 | — | — | EP | disclosed |
| WO-2012084678-A1 | NOVEL IMIDAZOLES USEFUL AS PLANT FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-06-28 | — | — | WO | disclosed |
| WO-2011124539-A1 | BICYCLIC PYRIMIDINYL PYRAZOLES | BAYER CROPSCIENCE AG (DE) | 2011-10-13 | — | — | WO | disclosed |
| US-20110251178-A1 | Bicyclic Pyridinylpyrazoles | BAYER CROPSCIENCE AG (DE) | 2011-10-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251178-A1 | Bicyclic Pyridinylpyrazoles | PLPBP, PNPO, PIR | GRM5 2077/4885KCNH2 727/4885FFAR1 4690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.