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PLPBP

Pyridoxal phosphate homeostasis protein · O94903 · PLPBP on Sugi Atlas →

1,838 patent compounds predicted against PLPBP, 1,625 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
Molibresib Molibresib (SCHEMBL1872390) 1.00 1/20
Molibresib Molibresib (SCHEMBL12671490) 1.00 1/20
Molibresib Molibresib (SCHEMBL12966358) 1.00 1/20
SCHEMBL9998851 SCHEMBL9998851 0.91 1/20
SCHEMBL14756282 SCHEMBL14756282 0.88 1/20
SCHEMBL15980874 SCHEMBL15980874 0.88 1/20
SCHEMBL12966165 SCHEMBL12966165 0.87 1/20
SCHEMBL14756215 SCHEMBL14756215 0.87 1/20
SCHEMBL14756339 SCHEMBL14756339 0.87 1/20
SCHEMBL15980861 SCHEMBL15980861 0.87 1/20
SCHEMBL9998825 SCHEMBL9998825 0.86 1/20
SCHEMBL15980893 SCHEMBL15980893 0.86 1/20
SCHEMBL15980803 SCHEMBL15980803 0.86 1/20
SCHEMBL1874116 SCHEMBL1874116 0.85 1/20
SCHEMBL12671221 SCHEMBL12671221 0.85 1/20
SCHEMBL14756021 SCHEMBL14756021 0.85 1/20
SCHEMBL14756240 SCHEMBL14756240 0.85 1/20
SCHEMBL14756287 SCHEMBL14756287 0.85 1/20
SCHEMBL14756335 SCHEMBL14756335 0.85 1/20
SCHEMBL14756409 SCHEMBL14756409 0.85 1/20

Clinical trials — most relevant to PLPBP by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Neuroprotective Effect of Vitamin B12 and Vitamin B6 Against Vincristine Induced Peripheral Neuropathy PHASE4COMPLETED
Risk Factors for Vascular Calcifications in Hemodialysis Patients: to What Extent is Vitamin K2 Deficiency Involved? PHASE4COMPLETED
AntiCoagulants and COGnition PHASE4UNKNOWN
Study of SGN1 Administered Via Intratumoral Injection in Patients With Advanced Solid Tumor PHASE1/PHASE2RECRUITING
Study of SGN1 in Patients With Advanced Solid Tumor PHASE1/PHASE2RECRUITING
Treatment of Nodding Syndrome - A Randomized Blinded Placebo-Controlled Crossover Trial of Oral Pyridoxine and Conventional Anti-Epileptic Therapy, in Northern Uganda - 2012 PHASE2WITHDRAWN
Safety, Tolerability and Pharmacokinetics of Benfo-Oxythiamine (B-OT) in Healthy Volunteers PHASE1COMPLETED
Pyridoxine, P2 Receptor Antagonism, and ATP-mediated Vasodilation in Young Adults EARLY_PHASE1COMPLETED
Unraveling Genetics of HypoPhosPhatasia (HPP Genetics) nanCOMPLETED
Study to Identify the Genetic Variations Associated With Phantom Limb Pain nanCOMPLETED
Randomized Controlled Clinical Trial to Investigate Effects of Vitamin K2 in COVID-19 nanCOMPLETED
Characterisation of Adult-Onset Hypophosphatasia nanCOMPLETED
Natural History Study of Patients With Hypophosphatasia (HPP) nanRECRUITING
Pyridoxine Effect on the Blood Glucose Level in Type 2 Diabetic Patients nanCOMPLETED
Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients nanUNKNOWN
Exome Sequencing for Atypical Femoral Fractures nanCOMPLETED
Plant-based Diets and Body Weight and Selected Metabolic Parameters Management in Obese Patients. nanCOMPLETED
High/Low Dose Vit A in Diarrhea/ALRI in Severe PEM nanCOMPLETED
The PORTRAIT Study nanUNKNOWN
Pseudoxanthoma Elasticum (PXE) Natural History Biomarkers in PXE Individuals and Their Biological Non-PXE Siblings nanCOMPLETED
Relationship of Haptoglobin Phenotype to Vascular Function and Response to Vitamin E Supplementation in Patients With Diabetes Mellitus Type 2: The EVAS Trial nanUNKNOWN
Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine Dependent Epilepsy Patients nanWITHDRAWN
Primary Hyperoxaluria Mutation Genotyping/Phenotyping nanCOMPLETED
Serum Zinc and Serum Magnesium in Chronic Liver Disease Patients nanCOMPLETED
Protein Synthesis in the Brain of Patients With Fragile X Syndrome nanCOMPLETED
Metabolic Availability of Lysine From Barley in Young Adult Men nanNOT_YET_RECRUITING
Development of an Optimal Micronutrient Reference Range for Adults nanCOMPLETED
Evaluating Changes in Skeletal Muscle Proteins Following Resistance Exercise and Single-Leg Disuse nanCOMPLETED
Institution of an Italian Multicenter Database of Patients Affected by Diseases of Phosphate Metabolism nanNOT_YET_RECRUITING
Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study) nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a PLPBP binder may also engage these)

ProteinNameSimilarity
Q5R4Z1 — 1.000 Q5R4Z1 →
Q3T0G5 — 1.000 Q3T0G5 →
Q9Z2Y8 — 1.000 Q9Z2Y8 →
Q01637 — 0.987 Q01637 →
P38197 — 0.983 P38197 →
P53720 — 0.983 P53720 →
P12928 — 0.983 P12928 →
P35914 — 0.982 P35914 →
P14965 — 0.982 P14965 →
Q9P6Q1 — 0.982 Q9P6Q1 →
O44006 — 0.982 O44006 →
A4ICE5 — 0.981 A4ICE5 →
Q8K582 — 0.981 Q8K582 →
Q0CFY3 — 0.981 Q0CFY3 →
Q6H6D2 — 0.981 Q6H6D2 →
P00908 — 0.980 P00908 →
O35435 — 0.980 O35435 →
P11980 — 0.980 P11980 →
A2ZCP0 — 0.980 A2ZCP0 →
P11155 — 0.980 P11155 →
P22360 — 0.980 P22360 →
P52480 — 0.980 P52480 →
Q43316 — 0.980 Q43316 →
P24920 — 0.980 P24920 →
Q12669 — 0.980 Q12669 →
P37116 — 0.979 P37116 →
Q29448 — 0.979 Q29448 →
P00931 — 0.979 P00931 →
B4PV71 — 0.979 B4PV71 →
Q8BTW8 — 0.979 Q8BTW8 →