SCHEMBL25304147

SCHEMBL25304147

COCOc1c(-c2cnc3cc(Br)ccc3n2)cc2cn(C)nc2c1F

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 6/20 0.33
FGFR2 P21802 6/20 0.33
FGFR4 P22455 6/20 0.33
FGFR3 P22607 6/20 0.33
KDR P35968 6/20 0.33
FLT3 P36888 4/20 0.33
HPGD P15428 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25306906 0.93 FGFR3 (0.34) FGFR1FGFR2FGFR4FGFR3KDR
SCHEMBL25842025 0.88 HPGD (0.33) FGFR1FGFR2FGFR4FGFR3KDR
SCHEMBL30492483 0.87
SCHEMBL25306418 0.87
SCHEMBL25261754 0.82 HRH4 (0.31) FGFR1FGFR2FGFR4FGFR3KDR
SCHEMBL30492557 0.82 HRH4 (0.31) FGFR1FGFR2FGFR4FGFR3KDR
SCHEMBL25256867 0.79 FGFR2 (0.37) FGFR1FGFR2FGFR4FGFR3KDR
SCHEMBL25300105 0.76 ALK (0.39)
SCHEMBL25201045 0.75 F2RL3 (0.31)
SCHEMBL25303658 0.75 HRH4 (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326748-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC (US) 2025-10-23 US disclosed
WO-2023133225-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-07-13 WO disclosed
WO-2023133225-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING REMIX THERAPEUTICS INC. (US) 2023-07-13 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250326748-A1 COMPOUNDS AND METHODS FOR MODULATING SPLICING RBM17, SNRPA, SNRPA1 FGFR1 4821/4885FGFR2 4766/4885FGFR4 4728/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.