Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 13/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510768 | 1.00 | PARP1 (0.38) | PARP1TNKSLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25309540 | 0.90 | JAK1 (0.37) | PARP1TNKSLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25309922 | 0.88 | PARP1 (0.38) | PARP1TNKSLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25307526 | 0.86 | PARP1 (0.42) | PARP1TNKSLMNAPARP2 | |
| SCHEMBL25308646 | 0.86 | PARP1 (0.42) | PARP1TNKSLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25313232 | 0.84 | PARP1 (0.46) | PARP1TNKSKMT2APARP2 | |
| SCHEMBL25309301 | 0.84 | PARP1 (0.39) | PARP1SMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL25311716 | 0.84 | PARP1 (0.42) | PARP1TNKSLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL25310262 | 0.84 | PARP1 (0.44) | PARP1TNKSLMNAPARP2 | |
| SCHEMBL25309986 | 0.84 | PARP1 (0.48) | PARP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |