Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.37 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510764 | 0.90 | CHRM1 (0.49) | PARP1CHRM1TNKSPARP2 | |
| SCHEMBL25310671 | 0.90 | CHRM1 (0.49) | PARP1CHRM1TNKSPARP2 | |
| SCHEMBL25307526 | 0.89 | PARP1 (0.42) | PARP1TNKSPARP2LMNA | |
| SCHEMBL25308646 | 0.89 | PARP1 (0.42) | PARP1TNKSPARP2LMNA | |
| SCHEMBL25311716 | 0.86 | PARP1 (0.42) | PARP1TNKSPARP2LMNA | |
| SCHEMBL25309986 | 0.86 | PARP1 (0.48) | PARP1CHRM4 | |
| SCHEMBL25309819 | 0.85 | GPR119 (0.40) | PARP1TNKSGPR119LMNA | |
| SCHEMBL25309301 | 0.85 | PARP1 (0.39) | PARP1CHRM4 | |
| SCHEMBL25312147 | 0.85 | PARP1 (0.39) | PARP1TNKSPARP2LMNA | |
| SCHEMBL30510776 | 0.85 | PARP1 (0.39) | PARP1TNKSPARP2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |