SCHEMBL25308469

SCHEMBL25308469

COc1c(F)cncc1C1CNC1

nearest known ligand 0.38

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ HTR2A P28223 1/20 0.38
▸ HTR2C P28335 1/20 0.38
▸ CHRNB2 P17787 6/20 0.38
▸ CHRNA4 P43681 6/20 0.38
▸ CHRNB4 P30926 5/20 0.38
▸ CHRNA3 P32297 5/20 0.38
▸ ALOX5AP P20292 3/20 0.32
▸ FEN1 P39748 3/20 0.32
▸ CYP11B2 P19099 2/20 0.31
▸ CHRNA7 P36544 1/20 0.31
▸ CYP11B1 P15538 1/20 0.30
▸ TGFBR1 P36897 1/20 0.30
▸ ACVR1 Q04771 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31250394 1.00 HTR2A (0.38) HTR2AHTR2CCHRNB2CHRNA4CHRNB4
SCHEMBL25306413 0.83 CHRNB2 (0.37) HTR2ACHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL31250383 0.83 CHRNB2 (0.37) HTR2ACHRNB2CHRNA4CHRNB4CHRNA3
SCHEMBL24952758 0.73 PDGFRB (0.38) CYP11B2CYP11B1
SCHEMBL25308429 0.69 CCNT1 (0.38) HTR2AHTR2CCHRNB2CHRNA4CHRNB4
SCHEMBL31250389 0.68 CHRNB2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL25306684 0.68 CHRNB2 (0.42) CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7
SCHEMBL31654140 0.68 HTR2C (0.46) HTR2AHTR2CCHRNB2CHRNA4CHRNB4
SCHEMBL25305763 0.68 HTR2A (0.39) HTR2AHTR2CCHRNB2CHRNA4CHRNB4
SCHEMBL31581935 0.68 HTR2C (0.46) HTR2AHTR2CCHRNB2CHRNA4CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250215029-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. 2025-07-03 — — US disclosed
EP-4463459-A1 STAT MODULATORS AND USES THEREOF Recludix Pharma, Inc. (US) 2024-11-20 — — EP disclosed
WO-2023133336-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. (US) 2023-07-13 — — WO disclosed
WO-2023133336-A1 STAT MODULATORS AND USES THEREOF RECLUDIX PHARMA, INC. (US) 2023-07-13 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250215029-A1 STAT MODULATORS AND USES THEREOF STAT6, STAT3, STAT5A HTR2A 3914/4885HTR2C 4265/4885CHRNB2 4847/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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