Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.53 |
| ▸ | TIPARP | Q7Z3E1 | 5/20 | 0.50 |
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30510755 | 1.00 | PARP1 (0.53) | PARP1TIPARPTNKSALDH1A1MEN1 | |
| SCHEMBL25310786 | 0.97 | TIPARP (0.53) | PARP1TIPARPTNKSALDH1A1MEN1 | |
| SCHEMBL30510774 | 0.97 | TIPARP (0.53) | PARP1TIPARPTNKSALDH1A1MEN1 | |
| SCHEMBL30510763 | 0.91 | KMT2A (0.57) | PARP1TIPARPALDH1A1MEN1MAPT | |
| SCHEMBL25310442 | 0.91 | KMT2A (0.57) | PARP1TIPARPALDH1A1MEN1MAPT | |
| SCHEMBL25311971 | 0.88 | KMT2A (0.56) | PARP1TIPARPALDH1A1MEN1MAPT | |
| SCHEMBL30510757 | 0.88 | KMT2A (0.56) | PARP1TIPARPALDH1A1MEN1MAPT | |
| SCHEMBL25309030 | 0.87 | TIPARP (0.63) | PARP1TIPARPTNKSKMT2A | |
| SCHEMBL25306468 | 0.85 | PARP1 (0.44) | PARP1TIPARPTNKSMAPTSMN1; SMN2 | |
| SCHEMBL30510760 | 0.85 | PARP1 (0.44) | PARP1TIPARPTNKSMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |