Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 12/20 | 0.44 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.38 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.38 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.38 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.38 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25306468 | 1.00 | PARP1 (0.44) | PARP1TIPARPTNKSADORA1CDK6 | |
| SCHEMBL25263476 | 0.91 | PARP1 (0.50) | PARP1MAPTSMN1; SMN2LCAT | |
| SCHEMBL30510759 | 0.91 | PARP1 (0.50) | PARP1MAPTSMN1; SMN2LCAT | |
| SCHEMBL30510765 | 0.89 | PARP1 (0.49) | PARP1TIPARPMAPTSMN1; SMN2LCAT | |
| SCHEMBL25309971 | 0.89 | PARP1 (0.49) | PARP1TIPARPMAPTSMN1; SMN2LCAT | |
| SCHEMBL25309986 | 0.88 | PARP1 (0.48) | PARP1TIPARPPKMMAPTSMN1; SMN2 | |
| SCHEMBL25309578 | 0.86 | SPR (0.43) | PARP1TNKSPARP2PKMMAPT | |
| SCHEMBL30510755 | 0.85 | PARP1 (0.53) | PARP1TIPARPTNKSPARP2MAPT | |
| SCHEMBL25308758 | 0.85 | PARP1 (0.53) | PARP1TIPARPTNKSPARP2MAPT | |
| SCHEMBL25310786 | 0.83 | TIPARP (0.53) | PARP1TIPARPTNKSMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |