Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.56 |
| ▸ | KDM1A | O60341 | 3/20 | 0.47 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CTSA | P10619 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | KDM4B | O94953 | 1/20 | 0.40 |
| ▸ | KDM5C | P41229 | 1/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309480 | 0.89 | KDM4C (0.69) | KDM4CKDM1ACTSAKDM5CKDM5B | |
| SCHEMBL26599271 | 0.79 | KDM1A (0.57) | KDM4CKDM1APARP1KDM4BKDM5C | |
| SCHEMBL29932915 | 0.75 | HDAC1 (0.58) | KDM4CKDM1AMAPK1KDM4BKDM5C | |
| SCHEMBL25306127 | 0.75 | SCN9A (0.47) | KDM1ASCN9APLAUCTSAPARP1 | |
| SCHEMBL30292668 | 0.73 | IKBKB (0.47) | KDM1ASCN9APLAUCTSAMKNK1 | |
| SCHEMBL31167842 | 0.72 | POLQ (0.45) | KDM1ASCN9APLAU | |
| SCHEMBL30526628 | 0.72 | POLQ (0.45) | KDM1ASCN9APLAU | |
| SCHEMBL25307617 | 0.72 | KDM1A (0.40) | KDM1ASCN9APLAUCTSA | |
| SCHEMBL11616908 | 0.72 | KDM1A (0.56) | KDM1APLAUTNIK | |
| SCHEMBL29932934 | 0.71 | HDAC1 (0.59) | KDM4CKDM1AMAPK1KDM4BKDM5C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134708-A1 | THIAZOLOPYRIDYL AMIDE DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | BEIGENE , LTD. (KY) | 2023-07-20 | — | — | WO | disclosed |