Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | INSR | P06213 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 7/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | KDM4B | O94953 | 1/20 | 0.46 |
| ▸ | KDM5C | P41229 | 1/20 | 0.46 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21310814 | 0.87 | KDM4C (0.69) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL29725136 | 0.87 | KDM4C (0.69) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL23552520 | 0.86 | KDM4C (0.60) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL31211671 | 0.86 | KDM4C (0.60) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL2126899 | 0.81 | KDM1A (0.54) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL4770667 | 0.81 | KDM1A (0.55) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL21311057 | 0.81 | KDM1A (0.53) | KDM1AHDAC1KDM4CHDAC6EGFR | |
| SCHEMBL2335933 | 0.81 | KDM4C (0.51) | KDM4CMKNK1MKNK2PARP1KDM4B | |
| SCHEMBL25308939 | 0.79 | KDM4C (0.56) | KDM1AHDAC1KDM4CEGFRMKNK1 | |
| SCHEMBL29933114 | 0.79 | KDM1A (0.53) | KDM1AHDAC1KDM4CHDAC6PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12162895-B2 | DNA polymerase theta inhibitor for treatment of cancer | BREAKPOINT THERAPEUTICS GMBH (DE) | 2024-12-10 | — | — | US | disclosed |
| US-20240336628-A1 | NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF | BREAKPOINT THERAPEUTICS GMBH (DE) | 2024-10-10 | — | — | US | disclosed |
| US-20240327430-A1 | NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF | BREAKPOINT THERAPEUTICS GMBH (DE) | 2024-10-03 | — | — | US | disclosed |
| WO-2023202623-A1 | POLQ INHIBITOR COMPOUND AND USE THEREOF | 南京再明医药有限公司 | 2023-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12162895-B2 | DNA polymerase theta inhibitor for treatment of cancer | POLQ, POLB, POLH | KDM1A 2125/4885HDAC1 445/4885KDM4C 2841/4885 |
| US-20240327430-A1 | NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF | POLQ, POLK, POLB | KDM1A 4049/4885HDAC1 347/4885KDM4C 3767/4885 |
| US-20240336628-A1 | NOVEL COMPOUNDS, COMPOSITIONS, AND THERAPEUTIC USES THEREOF | POLQ, POLK, POLB | KDM1A 4049/4885HDAC1 347/4885KDM4C 3767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.