Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 20/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25331029 | 0.93 | KRAS (0.40) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30493773 | 0.93 | KRAS (0.40) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31129488 | 0.93 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31129339 | 0.92 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31129721 | 0.92 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31129533 | 0.92 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL30864045 | 0.92 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31493993 | 0.92 | KRAS (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31049086 | 0.91 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL25263547 | 0.91 | KRAS (0.43) | KRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4655073-A2 | CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO | Arvinas Operations, Inc. (US) | 2025-12-03 | — | — | EP | disclosed |
| WO-2024159164-A2 | CEREBLON-BASED KRAS DEGRADING PROTACS ANS USES RELATED THERETO | ARVINAS OPERATIONS, INC. (US) | 2024-08-02 | — | — | WO | disclosed |
| WO-2023141570-A9 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2024-06-27 | — | — | WO | disclosed |
| WO-2023141570-A2 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF KRAS | ARVINAS OPERATIONS, INC. (US) | 2023-07-27 | — | — | WO | disclosed |