SCHEMBL31493993

COCOc1cc(-c2ncc3c(N4C[C@H]5CC[C@@H](C4)N5C(=O)OC(C)(C)C)nc(F)nc3c2F)c2c(C#C[Si](C(C)C)(C(C)C)C(C)C)c(F)ccc2c1

nearest known ligand 0.36

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	KRAS	P01116	18/20	0.36

▸	JAK1	P23458	2/20	0.35

▸	JAK2	O60674	1/20	0.35

▸	TYK2	P29597	1/20	0.35

▸	JAK3	P52333	1/20	0.35

▸	MAPK3	P27361	1/20	0.35

▸	MAPK1	P28482	1/20	0.35

▸	RAF1	P04049	2/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL31048829	0.95	KRAS (0.37)	KRASJAK1JAK2TYK2JAK3
SCHEMBL30260027	0.94	KRAS (0.36)	KRASJAK1JAK2TYK2JAK3
SCHEMBL30782214	0.93	JAK1 (0.35)	JAK1JAK2TYK2JAK3
SCHEMBL30779081	0.93	JAK1 (0.35)	JAK1JAK2TYK2JAK3
SCHEMBL25309618	0.93	KRAS (0.35)	KRASJAK1JAK2TYK2JAK3
SCHEMBL30148998	0.93	KRAS (0.35)	KRASJAK1JAK2TYK2JAK3
SCHEMBL30149009	0.93	KRAS (0.35)	KRASJAK1JAK2TYK2JAK3
SCHEMBL30149101	0.93	KRAS (0.38)	KRASJAK1JAK2TYK2JAK3
SCHEMBL25331029	0.93	KRAS (0.40)	KRASMAPK3MAPK1RAF1
SCHEMBL25437918	0.93	GPR119 (0.36)	KRASJAK1JAK2TYK2JAK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2025085815-A1	PROTAC COMPOUNDS BINDING KEAP1 UBIQUITIN LIGASE FOR TARGETED PROTEIN DEGRADATION	SEED THERAPEUTICS US, INC. (US)	2025-04-24	—	—	WO	disclosed
WO-2025083472-A2	PROTAC COMPOUNDS BINDING KEAP1 UBIQUITIN LIGASE FOR TARGETED PROTEIN DEGRADATION	SEED THERAPEUTICS US, INC. (US)	2025-04-24	—	—	WO	disclosed