Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 18/20 | 0.56 |
| ▸ | PARP1 | P09874 | 2/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.51 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.51 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.51 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309752 | 0.86 | PARP1 (0.59) | TIPARPPARP1CYP2C9PARP14PARP16 | |
| SCHEMBL25309030 | 0.83 | TIPARP (0.63) | TIPARPPARP1ROCK2ROCK1 | |
| SCHEMBL25309796 | 0.83 | TIPARP (0.67) | TIPARPPARP1ROCK2ROCK1 | |
| SCHEMBL25311903 | 0.82 | TIPARP (0.48) | TIPARPPARP1CYP2C9PARP14PARP16 | |
| SCHEMBL25312956 | 0.82 | PARP1 (0.59) | TIPARPPARP1CYP2C9PARP14PARP16 | |
| SCHEMBL25310607 | 0.81 | TIPARP (0.57) | TIPARPPARP1ROCK2ROCK1 | |
| SCHEMBL25262512 | 0.81 | PARP1 (0.61) | TIPARPPARP1ROCK2ROCK1 | |
| SCHEMBL25311169 | 0.81 | TIPARP (0.54) | TIPARPPARP1CYP2C9PARP14PARP16 | |
| SCHEMBL25309636 | 0.80 | TIPARP (0.59) | TIPARPPARP1ROCK2ROCK1 | |
| SCHEMBL27434555 | 0.79 | TIPARP (0.58) | TIPARPPARP1CYP2C9PARP14PARP16 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |