Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 12/20 | 0.59 |
| ▸ | PARP1 | P09874 | 5/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25309030 | 0.96 | TIPARP (0.63) | TIPARPPARP1ROCK2ROCK1KMT2A | |
| SCHEMBL25309796 | 0.94 | TIPARP (0.67) | TIPARPPARP1ROCK2ROCK1KMT2A | |
| SCHEMBL25309242 | 0.86 | PARP1 (0.52) | TIPARPPARP1ROCK2ROCK1KMT2A | |
| SCHEMBL25308900 | 0.86 | TIPARP (0.59) | TIPARPPARP1ROCK2ROCK1 | |
| SCHEMBL25262834 | 0.86 | TIPARP (0.62) | TIPARPPARP1 | |
| SCHEMBL30510769 | 0.86 | TIPARP (0.62) | TIPARPPARP1 | |
| SCHEMBL25308756 | 0.86 | TIPARP (0.62) | TIPARPPARP1 | |
| SCHEMBL25308789 | 0.86 | TNKS (0.51) | TIPARPPARP1KMT2ATNKS | |
| SCHEMBL25309193 | 0.85 | PARP1 (0.51) | TIPARPPARP1 | |
| SCHEMBL25310750 | 0.85 | ROCK2 (0.50) | TIPARPPARP1ROCK2ROCK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | claimed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |