Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.49 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ACACB | O00763 | 2/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30165102 | 1.00 | HDAC1 (0.57) | HDAC1HRH3KDM4ESMN1; SMN2ABL1 | |
| SCHEMBL18701834 | 0.86 | KDM4E (0.54) | HRH3KDM4ESMN1; SMN2ABL1LMNA | |
| SCHEMBL24962970 | 0.85 | GPR119 (0.57) | HDAC1HSD11B1GPR119ACACB | |
| SCHEMBL20468896 | 0.85 | HDAC1 (0.60) | HDAC1HRH3HSD11B1RETGPR119 | |
| SCHEMBL25310645 | 0.84 | HDAC1 (0.57) | HDAC1HSD11B1RETGPR119ACACB | |
| SCHEMBL30510782 | 0.84 | HDAC1 (0.57) | HDAC1HSD11B1RETGPR119ACACB | |
| SCHEMBL24428346 | 0.84 | HDAC1 (0.59) | HDAC1HSD11B1RETGPR119ACACB | |
| SCHEMBL21262007 | 0.84 | HDAC1 (0.59) | HDAC1HSD11B1RETGPR119 | |
| SCHEMBL22909889 | 0.84 | HDAC1 (0.59) | HDAC1HSD11B1RETGPR119ACACB | |
| SCHEMBL20456823 | 0.84 | HDAC1 (0.62) | HDAC1HSD11B1RETGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115745971-B | PARP7 inhibitor and application thereof | 北京华森英诺生物科技有限公司 | 2024-07-30 | — | — | CN | disclosed |
| WO-2023139536-A1 | (4-PIPERAZIN-1YL)-4-ALKYL-PHTHALAZIN-1(2H)-ONE COMPOUNDS AS PARP7 INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-07-27 | — | — | WO | disclosed |