Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17987159 | 0.82 | JAK1 (0.59) | JAK1JAK2TYK2 | |
| SCHEMBL19762846 | 0.79 | JAK1 (0.40) | JAK1NPC1RAB9AMAP3K5GAA | |
| SCHEMBL25311850 | 0.78 | LRRK2 (0.54) | — | |
| SCHEMBL25311848 | 0.78 | LRRK2 (0.54) | — | |
| SCHEMBL22971273 | 0.78 | LRRK2 (0.54) | — | |
| SCHEMBL3306389 | 0.76 | PTGS1 (0.51) | NPC1TP53RAB9AMAPTGAA | |
| SCHEMBL5353113 | 0.73 | JAK1 (0.42) | JAK1JAK2NPC1TP53RAB9A | |
| SCHEMBL29993826 | 0.71 | GAA (0.42) | JAK2NPC1RAB9ANTRK1MAPT | |
| SCHEMBL913680 | 0.71 | PTGS1 (0.58) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL2085478 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111892592-B | JAK kinase inhibitors and uses thereof | 江苏柯菲平医药股份有限公司 | 2023-09-19 | — | — | CN | disclosed |
| WO-2023138550-A1 | CYCLOPROPANAMIDE-CONTAINING COMPOUND AND USE THEREOF | 盛世泰科生物医药技术(苏州)有限公司 | 2023-07-27 | — | — | WO | disclosed |
| CN-114075189-A | Five-membered heterocyclic acene ring compound and preparation method and medical application thereof | 南京柯菲平盛辉制药有限公司 | 2022-02-22 | — | — | CN | disclosed |
| CN-111892592-A | JAK kinase inhibitors and uses thereof | 江苏柯菲平医药股份有限公司 | 2020-11-06 | — | — | CN | disclosed |
| CN-107428749-B | Substituted imidazo [1,2- α ] pyridin-2-ylamine compounds, pharmaceutical compositions and methods of use thereof | 上海复旦张江生物医药股份有限公司 | 2020-07-24 | — | — | CN | disclosed |