Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 3/20 | 0.33 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25311385 | 0.73 | JAK1 (0.40) | JAK1MAP3K5ALDH1A1GAAMAPT | |
| SCHEMBL5149569 | 0.65 | TGM2 (0.56) | MAOAPARP10MAPK14ALDH1A1MEN1 | |
| SCHEMBL5153495 | 0.64 | ALDH1A1 (0.58) | MAOAALDH1A1MEN1MITFGAA | |
| SCHEMBL913680 | 0.64 | PTGS1 (0.58) | ALDH1A1MAPTGFERSMN1; SMN2PTGS1 | |
| SCHEMBL1258121 | 0.63 | KDR (0.55) | JAK1ABL1METKDRLRRK2 | |
| SCHEMBL10352896 | 0.61 | MAOA (0.60) | MAOAKDM1AALDH1A1MEN1MITF | |
| SCHEMBL28535502 | 0.60 | MEN1 (0.63) | GRM5ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL4377108 | 0.60 | XIAP (0.62) | GRM5ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL5149570 | 0.60 | ALDH1A1 (0.53) | MAOAPARP10MAPK14ALDH1A1MEN1 | |
| Benzene SCHEMBL28182432 | 0.59 | MAOA (0.89) | MAOAPARP10KDM1AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249600-A1 | CHEMICAL COMPOUNDS | CHEUNG MUI | 2007-10-25 | — | — | US | disclosed |
| US-7238813-B2 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-03 | — | — | US | disclosed |
| US-20040082583-A1 | Chemical compounds | SMITHKLINE BEECHAM CORPORATION | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249600-A1 | CHEMICAL COMPOUNDS | TIE1, KDR, FLT4 | JAK1 82/4885GRM5 4033/4885MAOA 3005/4885 |
| US-20040082583-A1 | Chemical compounds | TIE1, KDR, FLT4 | JAK1 82/4885GRM5 4033/4885MAOA 3005/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.