Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Pentachlorophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pentachlorophenol SCHEMBL5859188 | 1.00 | TSHR (0.59) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL20812 | 0.97 | TSHR (0.62) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL8497787 | 0.94 | TSHR (0.59) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL11109917 | 0.89 | TSHR (0.53) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL7801029 | 0.88 | TSHR (0.67) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL28343301 | 0.84 | HPGD (0.71) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL17595225 | 0.81 | TSHR (0.50) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL6876934 | 0.81 | TSHR (0.43) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL15212565 | 0.80 | HSD17B10 (0.91) | TSHRHPGDHSD17B10MEN1ALDH1A1 | |
| Pentachlorophenol SCHEMBL41162 | 0.80 | HSD17B10 (0.91) | TSHRHPGDHSD17B10MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2561061-B2 | PROCESS FOR MAKING A DETERGENT BASE COMPOSITION | PROCTER & GAMBLE (US) | 2020-07-08 | — | — | EP | disclosed |
| EP-2561061-B1 | PROCESS FOR MAKING A DETERGENT BASE COMPOSITION | PROCTER & GAMBLE (US) | 2014-03-05 | — | — | EP | disclosed |
| US-8563497-B2 | Process for making a detergent based composition | THE PROCTER & GAMBLE COMPANY (US) | 2013-10-22 | — | — | US | disclosed |
| US-8461094-B2 | Process for making a liquid detergent composition comprising an alkanolamine/sodium ion-neutralized anionic surfactant | THE PROCTER & GAMBLE COMPANY (US) | 2013-06-11 | — | — | US | disclosed |
| EP-2561060-A1 | PROCESS FOR MAKING A LIQUID DETERGENT COMPOSITION | The Procter & Gamble Company (US) | 2013-02-27 | — | — | EP | disclosed |
| EP-2561061-A1 | PROCESS FOR MAKING A DETERGENT BASE COMPOSITION | The Procter & Gamble Company (US) | 2013-02-27 | — | — | EP | disclosed |
| WO-2011133378-A1 | PROCESS FOR MAKING A DETERGENT BASE COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011133305-A1 | PROCESS FOR MAKING A LIQUID DETERGENT COMPOSITION | THE PROCTER & GAMBLE COMPANY (US) | 2011-10-27 | — | — | WO | disclosed |
| US-20110252575-A1 | PROCESS FOR MAKING A LIQUID DETERGENT COMPOSITION | PROCTER & GAMBLE COMPANY, THE | 2011-10-20 | — | — | US | disclosed |
| US-20110252574-A1 | PROCESS FOR MAKING A DETERGENT BASED COMPOSITION | PROCTER & GAMBLE COMPANY, THE | 2011-10-20 | — | — | US | disclosed |
| EP-0611989-B1 | Solid processing composition for silver halide color photographic light-sensitive materials and processing method for the same | KONISHIROKU PHOTO IND (JP) | 1997-11-19 | — | — | EP | disclosed |
| EP-0611989-A1 | Solid processing composition for silver halide color photographic light-sensitive materials and processing method for the same | KONICA CORPORATION (JP) | 1994-08-24 | — | — | EP | disclosed |