Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | QPCT | Q16769 | 1/20 | 0.34 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25310932 | 0.93 | MAPT (0.44) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL10699834 | 0.83 | MAPT (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL718877 | 0.78 | MAPT (0.47) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL13154646 | 0.75 | DRD2 (0.44) | MAPTALDH1A1CHRNB2CHRNA4DRD2 | |
| SCHEMBL22495923 | 0.75 | CA9 (0.42) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL9379485 | 0.73 | KDM4E (0.46) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL19415553 | 0.73 | MAPT (0.50) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL3589727 | 0.73 | KDM4E (0.50) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL29339065 | 0.73 | MAPT (0.50) | MAPTKDM4EALDH1A1APEX1RECQL | |
| SCHEMBL30798763 | 0.71 | MAPT (0.41) | MAPTKDM4EALDH1A1APEX1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4466259-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2024-11-27 | — | — | EP | disclosed |
| US-20240366581-A1 | BENZIMIDAZOLE PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2024-11-07 | — | — | US | disclosed |
| WO-2023139084-A1 | NEW BENZIMIDAZOLE PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2023-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240366581-A1 | BENZIMIDAZOLE PYRIDINE DERIVATIVES | SIK3, JAK1, SIK2 | MAPT 3318/4885KDM4E 1963/4885ALDH1A1 1189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.