Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30467035 | 0.91 | BRAF (0.39) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25910289 | 0.69 | BRAF (0.49) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25913433 | 0.69 | BRAF (0.46) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25910556 | 0.69 | PDGFRB (0.49) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25910799 | 0.68 | BRAF (0.46) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25910809 | 0.68 | BRAF (0.45) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25910564 | 0.67 | BRAF (0.46) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25914667 | 0.67 | BRAF (0.44) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25912681 | 0.67 | BRAF (0.46) | BRAFLCKFYNPDGFRBKIT | |
| SCHEMBL25909917 | 0.66 | PDGFRB (0.52) | BRAFLCKFYNPDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |