Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 12/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | FLT1 | P17948 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25910556 | 0.83 | PDGFRB (0.49) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25913446 | 0.82 | MAOA (0.35) | BRAF | |
| SCHEMBL25912681 | 0.82 | BRAF (0.46) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25910809 | 0.82 | BRAF (0.45) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25910421 | 0.81 | PDGFRB (0.48) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25910564 | 0.81 | BRAF (0.46) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25910799 | 0.80 | BRAF (0.46) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25909917 | 0.80 | PDGFRB (0.52) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25910289 | 0.80 | BRAF (0.49) | BRAFPDGFRBLCKFYNKIT | |
| SCHEMBL25910828 | 0.80 | BRAF (0.45) | BRAFPDGFRBLCKFYNKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125812-A1 | SUBSTITUTED PYRIMIDONE DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND MEDICAL USE THEREOF | 上海海雁医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |