Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 19/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25897700 | 0.77 | TYK2 (0.53) | TYK2JAK2 | |
| SCHEMBL25897804 | 0.77 | TYK2 (0.57) | TYK2JAK2 | |
| SCHEMBL27238483 | 0.77 | TYK2 (0.62) | TYK2JAK2 | |
| SCHEMBL29810661 | 0.77 | TYK2 (0.62) | TYK2JAK2 | |
| SCHEMBL25897582 | 0.75 | TYK2 (0.61) | TYK2JAK2 | |
| SCHEMBL25316571 | 0.74 | TYK2 (0.50) | TYK2JAK2 | |
| SCHEMBL25573296 | 0.74 | TYK2 (0.57) | TYK2JAK2 | |
| SCHEMBL29810656 | 0.73 | TYK2 (0.58) | TYK2JAK2 | |
| SCHEMBL27238530 | 0.73 | TYK2 (0.58) | TYK2JAK2 | |
| SCHEMBL25573307 | 0.72 | TYK2 (0.57) | TYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242546-A1 | SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, AND 1,2,4-TRIAZINES AS TYK2 INHIBITORS | SUDO BIOSCIENCES LIMITED (GB) | 2023-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242546-A1 | SUBSTITUTED PYRIDINES, PYRIDAZINES, PYRIMIDINES, AND 1,2,4-TRIAZINES AS TYK2 INHIBITORS | TYK2, PDXK, JAK1 | TYK2 1/4885JAK2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.