Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RAD52 | P43351 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 11/20 | 0.47 |
| ▸ | BCHE | P06276 | 8/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30770846 | 0.99 | TLR8 (0.50) | TLR8POLBRAD52KDM4ETTR | |
| SCHEMBL250447 | 0.99 | TLR8 (0.50) | TLR8POLBRAD52KDM4ETTR | |
| SCHEMBL10424918 | 0.75 | SLC2A1 (0.46) | TLR8POLBRAD52KDM4EACHE | |
| SCHEMBL9748474 | 0.74 | POLB (0.70) | POLBRAD52KDM4ETTRGLA | |
| SCHEMBL28465683 | 0.72 | TLR8 (0.44) | TLR8POLBRAD52KDM4ETTR | |
| SCHEMBL9755341 | 0.71 | POLB (0.55) | TLR8POLBRAD52KDM4EGLA | |
| SCHEMBL5393759 | 0.71 | TLR8 (0.59) | TLR8POLBRAD52KDM4EGLA | |
| SCHEMBL27459127 | 0.70 | TLR8 (0.58) | TLR8KDM4EGAAMAPTCACNA2D1 | |
| SCHEMBL27512057 | 0.70 | TLR8 (0.58) | TLR8KDM4EGAAMAPTCACNA2D1 | |
| SCHEMBL8418578 | 0.70 | TLR8 (0.50) | TLR8POLBRAD52KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9192656-B2 | Methods and compositions for the treatment of cancer | QUINTESSENCE BIOSCIENCES, INC. (US) | 2015-11-24 | — | — | US | disclosed |
| US-9006407-B2 | Therapeutic ribonucleases | QUINTESSENCE BIOSCIENCES, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| US-20140128457-A1 | THERAPEUTIC RIBONUCLEASES | QUINTESSENCE BIOSCIENCES, INC. (US) | 2014-05-08 | — | — | US | disclosed |
| US-20130078229-A1 | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER | QUINTESSENCE BIOSCIENCES, INC. | 2013-03-28 | — | — | US | disclosed |
| US-20120276077-A1 | THERAPEUTIC RIBONUCLEASES | QUINTESSENCE BIOSCIENCES, INC. (US) | 2012-11-01 | — | — | US | disclosed |
| US-8298801-B2 | Human ribonuclease for use in prevention and treatment of cancer; antitumor agents | QUINTESSENCE BIOSCIENCES, INC. (US) | 2012-10-30 | — | — | US | disclosed |
| US-8029782-B2 | Therapeutic ribonucleases | QUINTESSENCE BIOSCIENCES, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20100080789-A1 | THERAPEUTIC RIBONUCLEASES | QUINTESSENCE BIOSCIENCES, INC. (US) | 2010-04-01 | — | — | US | disclosed |
| US-20080095755-A1 | Methods and compositions for the treatment of cancer | QUINTESSENCE BIOSCIENCES, INC. (US) | 2008-04-24 | — | — | US | disclosed |