Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.33 |
| ▸ | MELK | Q14680 | 3/20 | 0.33 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 2/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | WNT1 | P04628 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | CLK3 | P49761 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.30 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25912068 | 0.88 | TLR8 (0.38) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL29081534 | 0.88 | TLR8 (0.38) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL25912011 | 0.88 | TLR8 (0.38) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL29081533 | 0.88 | TLR8 (0.38) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL25323890 | 0.88 | IRAK4 (0.37) | TLR8KDM5AIRAK4GSK3BDYRK1A | |
| SCHEMBL25322655 | 0.84 | TLR8 (0.37) | TLR8 | |
| SCHEMBL29081922 | 0.83 | TLR8 (0.37) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL29081246 | 0.83 | TLR8 (0.37) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL29081248 | 0.83 | TLR8 (0.37) | TLR8KDM5AIRAK4MELKCHEK2 | |
| SCHEMBL25911939 | 0.83 | TLR8 (0.40) | TLR8KDM5AIRAK4CHEK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146990-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |