Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2532009 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL2528750 | 0.86 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL2528748 | 0.86 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL10384913 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL10384911 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL10385009 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL10384258 | 0.83 | KDM4E (0.75) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL8145721 | 0.81 | KDM4E (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL4572933 | 0.81 | KDM4E (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 | |
| SCHEMBL29637239 | 0.81 | KDM4E (0.73) | KDM4EALDH1A1HPGDL3MBTL1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558459-B1 | PHTHALAZIN-(2H)-ONE INHIBITORS OF KINASES | ABBVIE INC (US) | 2014-01-22 | — | — | EP | disclosed |
| US-8383623-B2 | Phthalazin-(2H)-one inhibitors of kinases | ABBOTT LABORATORIES (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2558459-A1 | PHTHALAZIN-(2H)-ONE INHIBITORS OF KINASES | Abbvie Inc. (US) | 2013-02-20 | — | — | EP | disclosed |
| WO-2011130478-A1 | PHTHALAZIN-(2H)-ONE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-10-20 | — | — | WO | disclosed |
| US-20110257187-A1 | PHTHALAZIN-(2H)-ONE INHIBITORS OF KINASES | ABBOTT LABORATORIES (US) | 2011-10-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110257187-A1 | PHTHALAZIN-(2H)-ONE INHIBITORS OF KINASES | CDC7, CDK17, CDK1 | KDM4E 1246/4885ALDH1A1 3626/4885HPGD 3750/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.