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Sugi Predict / Compounds / SCHEMBL25320360

SCHEMBL25320360

SCHEMBL25320360

CCOC(=O)C(=O)N1C[C@@H](C)CC[C@@H]1c1ccc2ccc(C3CCN(C)CC3)nc2c1.C[C@H]1CC[C@H](c2ccc3ccc(C4CCN(C)CC4)nc3c2)N(C(=O)C(N)=O)C1

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 20/20 0.37
▸ WDR77 Q9BQA1 3/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25323365 0.96 PRMT5 (0.38) PRMT5WDR77
SCHEMBL25321408 0.91 PRMT5 (0.42) PRMT5WDR77
SCHEMBL25323805 0.90 PRMT5 (0.33) PRMT5WDR77
SCHEMBL25323151 0.84 PRMT5 (0.36) PRMT5WDR77
SCHEMBL25320591 0.81 PRMT5 (0.36) PRMT5WDR77
SCHEMBL31578425 0.79 PRMT5 (0.36) PRMT5WDR77
SCHEMBL25320685 0.78 PRMT5 (0.41) PRMT5WDR77
SCHEMBL30551287 0.78 PRMT5 (0.41) PRMT5WDR77
SCHEMBL24364900 0.78 PRMT5 (0.44) PRMT5WDR77
SCHEMBL25322991 0.77 PRMT5 (0.46) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469455-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 — — EP disclosed
WO-2023146990-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 — — WO disclosed