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Sugi Predict / Compounds / SCHEMBL25320591

SCHEMBL25320591

SCHEMBL25320591

CCOC(=O)C(=O)N1C[C@@H](C)CC[C@@H]1c1ccc2nn(C3CCN(C)CC3)cc2c1.C[C@H]1CC[C@H](c2ccc3nn(C4CCN(C)CC4)cc3c2)N(C(=O)C(N)=O)C1

nearest known ligand 0.36

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 17/20 0.36
▸ IRAK4 Q9NWZ3 3/20 0.36
▸ WDR77 Q9BQA1 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25323261 0.96 PRMT5 (0.36) PRMT5IRAK4WDR77
SCHEMBL25323151 0.94 PRMT5 (0.36) PRMT5IRAK4WDR77
SCHEMBL25321682 0.92 PRMT5 (0.41) PRMT5IRAK4WDR77
SCHEMBL25321989 0.90 IRAK4 (0.34) PRMT5IRAK4WDR77
SCHEMBL31578425 0.89 PRMT5 (0.36) PRMT5IRAK4WDR77
SCHEMBL25322007 0.89 PRMT5 (0.36) PRMT5IRAK4WDR77
SCHEMBL25320241 0.85 PRMT5 (0.39) PRMT5WDR77
SCHEMBL30551319 0.85 PRMT5 (0.39) PRMT5WDR77
SCHEMBL25325232 0.85 PRMT5 (0.41) PRMT5IRAK4WDR77
SCHEMBL25320360 0.81 PRMT5 (0.37) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469455-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 — — EP disclosed
WO-2023146990-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 — — WO disclosed