Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tenalisib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD known ✓ | O00329 | 16/20 | 0.78 |
| ▸ | PIK3CG known ✓ | P48736 | 3/20 | 0.78 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tenalisib SCHEMBL25320577 | 1.00 | PIK3CD (0.78) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL30157094 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL29547168 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL16279460 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL16279279 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL16279824 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL29369874 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL29506722 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL30256608 | 0.99 | PIK3CD (0.79) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 | |
| Tenalisib SCHEMBL25295460 | 0.98 | PIK3CD (0.78) | PIK3CDPIK3CGRPS6KB1PIK3R2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116410195-A | Adipic acid salt crystal and preparation method thereof | 同润生物医药(上海)有限公司 | 2023-07-11 | — | — | CN | disclosed |
| WO-2023125419-A1 | ADIPATE CRYSTAL AND PREPARATION METHOD THEREFOR | 同润生物医药(上海)有限公司 | 2023-07-06 | — | — | WO | disclosed |