Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28408986 | 0.86 | KCNH2 (0.33) | SMN1; SMN2TSHRALDH1A1KDM4EKMT2A | |
| SCHEMBL15018821 | 0.83 | CHEK1 (0.35) | SMN1; SMN2TSHRGAAALDH1A1CA12 | |
| Hydrochloric Acid SCHEMBL28580531 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2TSHRGAAALDH1A1ADRA2B | |
| SCHEMBL6363966 | 0.82 | KDM4E (0.50) | SMN1; SMN2TSHRGAAALDH1A1ADRA2B | |
| SCHEMBL25319984 | 0.82 | KMT2A (0.33) | SMN1; SMN2TSHRGAAALDH1A1KDM4E | |
| SCHEMBL25320420 | 0.82 | KMT2A (0.37) | ALDH1A1KMT2APOLBHPGD | |
| SCHEMBL1094492 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2TSHRGAAALDH1A1ADRA2B | |
| Hydrochloric Acid SCHEMBL28571903 | 0.80 | SMN1; SMN2 (0.44) | SMN1; SMN2TSHRGAAALDH1A1ADRA2B | |
| SCHEMBL25322639 | 0.78 | NAMPT (0.37) | SMN1; SMN2TSHRGAAALDH1A1KDM4E | |
| SCHEMBL28375829 | 0.76 | TOP2A (0.36) | SMN1; SMN2TSHRALDH1A1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4215525-A1 | PIPERAZINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF | Zhejiang Hisun Pharmaceutical Co., Ltd. (CN) | 2023-07-26 | — | — | EP | disclosed |
| CN-116348109-A | Piperazine derivative, and preparation method and application thereof | 浙江海正药业股份有限公司 | 2023-06-27 | — | — | CN | disclosed |